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Lamellar thickness transition of melt-crystallized polybuten-1 tetragonal phase: configurational change in chainfolding directions

Motoi YAMASHITA

《化学科学与工程前沿（英文）》 2009年 第3卷 第1期   页码 26-32 doi: 10.1007/s11705-009-0002-2

摘要： Lamellar crystal thickness of isotactic polybutene-1 ( -PB1) have been investigated for crystallization in the melt over a wide range of crystallization temperature from 40°C to 90°C by small angle X-ray scattering experiments and density measurements. The crystal thickness demonstrates two linear dependences on inverse supercooling and a transition from one dependence to the other has been observed around = 65°C. Each of the two dependences obeys the nucleation theory in the high and low supercooling ranges, respectively. Chain folding free energy determined from the low supercooling range is larger than that determined from the high supercooling range. Possible mechanisms for the transition are discussed taking account of entropy of chain folding directions.

关键词： isotactic polybutene-1     tetragonal phase     crystal thickness     melt growth     chain folding     small angle X-ray scattering     nucleation theory     end surface free energy    

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Pricing and production strategies in remanufacturing from the perspectives of supply chain: Review and

《工程管理前沿（英文）》 doi: 10.1007/s42524-023-0251-7

摘要： Remanufacturing is widely recognized as beneficial to the environment and a circular economy. However, remanufacturing is more complex than traditional manufacturing due to the effects of government policy, uncertainty of consumer preferences, competition and cooperation among firms, and so on. These factors motivate academics to optimize remanufacturing outcomes, especially for product pricing and production. This study reviews the published literature on pricing and production strategies in remanufacturing from four perspectives of supply chain, namely, government policy, consumer characteristics, relationships among firms, and supply chain structures. Review results can benefit scholars/practitioners in the future by highlighting the challenges and opportunities in remanufacturing strategies.

关键词： remanufacturing     reverse and closed-loop supply chain     circular economy    

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Modeling of the resilient supply chain system from a perspective of production design changes

《工程管理前沿（英文）》   页码 96-106 doi: 10.1007/s42524-022-0235-z

摘要： Building an effective resilient supply chain system (RSCS) is critical and necessary to reduce the risk of supply chain disruptions in unexpected scenarios such as COVID-19 pandemic and trade wars. To overcome the impact of insufficient raw material supply on the supply chain in mass disruption scenarios, this study proposes a novel RSCS considering product design changes (PDC). An RSCS domain model is first developed from the perspective of PDC based on a general conceptual framework, i.e., function-context-behavior-principle-state-structure (FCBPSS), which can portray complex systems under unpredictable situations. Specifically, the interaction among the structure, state and behavior of the infrastructure system and substance system is captured, and then a quantitative analysis of the change impact process is presented to evaluate the resilience of both the product and supply chain. Next, a case study is conducted to demonstrate the PDC strategy and to validate the feasibility and effectiveness of the RSCS domain model. The results show that the restructured RSCS based on the proposed strategy and model can remedy the huge losses caused by the unavailability of raw materials.

关键词： resilient supply chain     supply chain disruption     domain modeling     product design changes    

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Production of rhamnolipids-producing enzymes of

Kata Kiss,Wei Ting Ng,Qingxin Li

《化学科学与工程前沿（英文）》 2017年 第11卷 第1期   页码 133-138 doi: 10.1007/s11705-017-1637-z

摘要： Rhamnolipids are a class of biosurfactants that have a great potential to be used in industries. Five proteins/enzymes, namely RhlA, RhlB, RhlC, RhlG and RhlI, are critical for the production of rhamnolipids in . Four of the 5 proteins except RhlC were successfully over-expressed in and three of them (RhlA, RhlB and RhlI) were purified and obtained in milligram quantities. The purified proteins were shown to be folded in solution. Homology models were built for RhlA, RhlB and RhlI. These results lay a basis for further structural and functional characterization of these proteins to favor the construction of super strains for rhamnolipids production.

关键词： rhamnolipids     Pseudomonas     RhlA     RhlB     RhlI     protein folding    

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Digitalization for supply chain resilience and robustness: The roles of collaboration and formal contracts

《工程管理前沿（英文）》   页码 5-19 doi: 10.1007/s42524-022-0229-x

摘要： Black swan events such as the coronavirus (COVID-19) outbreak cause substantial supply chain disruption risks to modern companies. In today’s turbulent and complex business environment, supply chain resilience and robustness as two critical capabilities for firms to cope with disruptions have won substantial attention from both the academia and industry. Accordingly, this study intends to explore how digitalization helps build supply chain resilience and robustness. Adopting organizational information processing theory, it proposes the mediating effect of supply chain collaboration and the moderating effect of formal contracts. Using survey data of Chinese manufacturing firms, the study applied structural equation modelling to test the research model. Results show that digitalization has a direct effect on supply chain resilience, and supply chain collaboration can directly facilitate both resilience and robustness. Our study also indicates a complementary mediating effect of supply chain collaboration on the relationship between digitalization and supply chain resilience and an indirect-only mediation effect on the relationship between digitalization and supply chain robustness. Findings reveal the differential roles of digitalization as a technical factor and supply chain collaboration as an organizational factor in managing supply chain disruptions. Paradoxically, formal contracts enhance the relationship between digitalization and supply chain resilience but weaken the relationship between supply chain collaboration and supply chain resilience. The validation of moderating effects determines the boundary conditions of digitalization and supply chain collaboration and provides insights into governing supply chain partners’ behavior. Overall, this study enhances the understanding on how to build a resilient and robust supply chain.

关键词： digitalization     supply chain     resilience     robustness     collaboration     formal contract    

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Disruptive technologies for advancing supply chain resilience

《工程管理前沿（英文）》 2023年 第10卷 第2期   页码 360-366 doi: 10.1007/s42524-023-0257-1

摘要： Disruptive technologies provide a new paradigm for supply chain risk management and bring opportunities and challenges for the improvement of supply chain resilience (SCRes). This study summarizes the application cases of some disruptive technologies in the SCRes and analyzes the benefits and damages brought by disruptive technologies to the SCRes. The results show that disruptive technologies can provide the supply chain with flexibility, visibility, agility, and other capabilities at various stages of risk management. Hence, technology advancements greatly increase the level of the SCRes. Although disruptive technologies undermine the construction of SCRes, these damages can be eliminated through technology iteration or other disruptive technologies. Furthermore, disruptive technologies will provide better stability for the SCRes. The study also makes several suggestions for the use of disruptive technologies in the construction of the SCRes.

关键词： supply chain resilience     disruptive technology     supply chain risk    

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Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

《工程管理前沿（英文）》   页码 82-95 doi: 10.1007/s42524-022-0233-1

摘要： During the COVID-19 pandemic, the current operating environment of pharmaceutical supply chain (PSC) has rapidly changed and faced increasing risks of disruption. The Internet of Things (IoT) and blockchain not only help enhance the efficiency of PSC operations in the information technology domain but also address complex related issues and improve the visibility, flexibility, and transparency of these operations. Although IoT and blockchain have been widely examined in the areas of supply chain and logistics management, further work on PSC is expected by the public to enhance its resilience. To respond to this call, this paper combines a literature review with semi-structured interviews to investigate the characteristics of PSC, the key aspects affecting PSC, and the challenges faced by PSC in the post-pandemic era. An IoT–blockchain-integrated hospital-side oriented PSC management model is also developed. This paper highlights how IoT and blockchain technology can enhance supply chain resilience and provides a reference on how PSC members can cope with the associated risks.

关键词： pharmaceutical supply chain     Internet of Things     blockchain     resilience     post-pandemic era    

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Advancing food supply chain resilience in the post-pandemic era

《工程管理前沿（英文）》   页码 107-120 doi: 10.1007/s42524-022-0232-2

摘要： In the post-pandemic era, food supply chains and firms therein are facing unprecedented severe challenges, because once infection is detected, numerous products must be recalled or abandoned, and both suppliers and retailers in the supply chain suffer enormous loss. To survive under the pandemic, retailers have adopted different sourcing strategies, such as contingent sourcing, which, in turn, affect the upstream suppliers and hence the resilience of the whole supply chain. With the rapid development of digital technologies, retailers nowadays can utilize blockchain as a reliable and efficient way to reduce product risk and hence advance the resilience of food supply chains by improving product traceability and inspection accuracy, and making sourcing transparent. In this paper, we develop a game-theoretic model to investigate the interrelation between the retailer’s decisions on blockchain adoption and sourcing strategies. We consider that a retailer originally orders from a risky supplier while conducting an imperfect inspection to detect infected products before selling. The retailer may speculatively keep on ordering from the risky supplier or adopt contingent sourcing by ordering from an alternative safe supplier. The retailer also has an option to implement blockchain to improve the inspection accuracy and product traceability. We derive the optimal retail prices under different sourcing strategies with and without blockchain adoption and then analyze the incentives for sourcing strategy and blockchain adoption. Then, we identify the conditions of an all-win situation for food retailer, supplier, supply chain resilience, and consumers with/without government subsidy. Finally, we extend to consider the situation that some consumers have health-safety concerns and preferences for blockchain adoption.

关键词： food supply chain     blockchain     contingent sourcing     supply chain resilience    

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Managing supply chain resilience in the era of VUCA

Ying GAO , Zhuo FENG , Shuibo ZHANG

《工程管理前沿（英文）》 2021年 第8卷 第3期   页码 465-470 doi: 10.1007/s42524-021-0164-2

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国外ICT供应链安全管理研究及建议

倪光南,陈晓桦,尚燕敏、徐克付

《中国工程科学》 2016年 第18卷 第6期   页码 104-109 doi: 10.15302/J-SSCAE-2016.06.021

摘要：

鉴于国家关键基础设施和关键资源（CIKR）对信息通信技术（ICT）的依赖，识别和控制ICT供应链风险已成为保障国家安全的重要手段。美国作为ICT供应链管理的先行者，在提升战略地位、开展风险管理、确保软硬件安全、监管政府采购等方面为各国提供了丰富经验；欧盟、俄罗斯也加强了ICT供应链的安全管理。在分析上述国外情况的基础上，给出了完善我国ICT供应链安全管理的相关建议。

关键词： 供应链风险管理     硬件供应链     软件供应链     采购安全    

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Digital twin-driven smart supply chain

《工程管理前沿（英文）》 2022年 第9卷 第1期   页码 56-70 doi: 10.1007/s42524-021-0186-9

摘要： Today’s supply chain is becoming complex and fragile. Hence, supply chain managers need to create and unlock the value of the smart supply chain. A smart supply chain requires connectivity, visibility, and agility, and it needs be integrated and intelligent. The digital twin (DT) concept satisfies these requirements. Therefore, we propose creating a DT-driven supply chain (DTSC) as an innovative and integrated solution for the smart supply chain. We provide background information to explain the DT concept and to demonstrate the method for building a DTSC by using the DT concept. We discuss three research opportunities in building a DTSC, including supply chain modeling, real-time supply chain optimization, and data usage in supply chain collaboration. Finally, we highlight a motivating case from JD.COM, China’s largest retailer by revenue, in applying the DTSC platform to address supply chain network reconfiguration challenges during the COVID-19 pandemic.

关键词： digital twin     supply chain management    

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hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chainand the rat light chain

《医学前沿（英文）》 2022年 第16卷 第4期   页码 584-595 doi: 10.1007/s11684-021-0844-7

摘要： Conventional therapies for hemophilia A (HA) are prophylactic or on-demand intravenous FVIII infusions. However, they are expensive and inconvenient to perform. Thus, better strategies for HA treatment must be developed. In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulant potential for adeno-associated virus (AAV)-delivered gene therapy was developed. Plasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC) were transfected into cells and hydrodynamically injected into HA mice. Purified AAV viruses were intravenously injected into HA mice at two doses. Results showed that the hHC+ rLC protein had a higher activity than the hHC+ hLC protein at comparable expression levels. The specific activity of hHC+ rLC was about 4- to 8-fold higher than that of their counterparts. Hydrodynamic injection experiments obtained consistent results. Notably, the HA mice undergoing the AAV-delivered hHC+ rLC treatment exhibited a visibly higher activity than those treated with hHC+ hLC, and the therapeutic effects lasted for up to 40 weeks. In conclusion, the application of the hybrid FVIII (hHC+ rLC) via an AAV-delivered gene therapy substantially improved the hemorrhagic diathesis of the HA mice. These data might be of help to the development of optimized FVIII expression cassette for HA gene therapy.

关键词： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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Product decomposition strategy for optimization of supply chain planning

Braulio BRUNAUD, Maria Paz OCHOA, Ignacio E. GROSSMANN

《工程管理前沿（英文）》 2018年 第5卷 第4期   页码 466-478 doi: 10.15302/J-FEM-2018059

摘要：

Optimization of large-scale supply chain planning models requires the application of decomposition strategies to reduce the computational expense. Two major options are to use either spatial or temporal Lagrangean decomposition. In this paper, to further reduce the computational expense a novel decomposition scheme by products is presented. The decomposition is based on a reformulation of knapsack constraints in the problem. The new approach allows for simultaneous decomposition by products and by time periods, enabling the generation of a large number of subproblems, that can be solved by using parallel computing. The case study shows that the proposed product decomposition exhibits similar performance as the temporal decomposition, and that selecting different orders of products and aggregating the linking constraints can improve the efficiency of the algorithm.

关键词： supply chain planning     Lagrangean decomposition     mixed-integer programming    

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Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells

Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO

《农业科学与工程前沿（英文）》 2014年 第1卷 第3期   页码 201-213 doi: 10.15302/J-FASE-2014017

摘要： In the bone marrow and spleen, the developing B cell populations undergo both negative and positive selections to shape their B cell receptor repertoire. To gain insight into the shift of the immunoglobulin heavy (IgH) chain repertoire during B cell development, we undertook large scale Ig μ chain repertoire analysis of pre-B, immature B and spleen B cell populations. We found that the majority of V gene segments, V families, J and D gene segments, were observed to have significantly different usage frequencies when three B cell populations were compared, but the usage profile of the V D, and J genes between different B cell populations showed high correlations. In both productive and nonproductive rearrangements, the length of CDRH3 shortened significantly on average when B cells entered the periphery. However, the CDRH3 length distribution of nonproductive rearrangements did not follow a Gaussian distribution, but decreased successively in the order 3 -2, 3 -1 and 3 , suggesting a direct correlation between mRNA stability and CDRH3 length patterns of nonproductive rearrangements. Further analysis of the individual components comprising CDRH3 of productive rearrangements indicated that the decrease in CDRH3 length was largely due to the reduction of N addition at the 5′ and 3′ junctions. Moreover, with development, the amino acid content of CDRH3 progressed toward fewer positively charged and nonpolar residues but more polar residues. All these data indicated that the expressed Ig μ chain repertoire, especially the repertoire of CDRH3, was fine-tuned when B cells passed through several checkpoints of selection during the process of maturation.

关键词： repertoire     complementarity determining region 3 of the IgH chain (CDRH3)     immunoglobulin     heavy chain     variable region    

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How do digital technologies improve supply chain resilience in the COVID-19 pandemic?

《工程管理前沿（英文）》   页码 39-50 doi: 10.1007/s42524-022-0230-4

摘要： Digital technologies (DTs) can assist businesses in coping with supply chain (SC) disruptions caused by unpredictability, such as pandemics. However, the current knowledge of the relationship between DTs and supply chain resilience (SCR) is insufficient. This study draws on information processing theory to develop a serial mediation model to address this deficiency. We analyze a sample set consisting of 264 Chinese manufacturers. The empirical results reveal that digital supply chain platforms (DSCPs), as well as supply chain traceability (SCT) and supply chain agility (SCA), fully mediate the favorable association between DTs and SCR. Specifically, the four significant indirect paths indicated that firms can improve SCR only if they use DTs to directly or indirectly improve SCT and SCA (through DSCPs). Our study contributes to the literature on resilience by examining the possible mechanism of mediation through which DTs influence SCR. The findings also offer essential insights for firms to modify their digital strategies and thrive in a turbulent environment.

关键词： digital technologies     supply chain resilience     information processing theory     COVID-19     China    

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标题 作者 时间 类型 操作

Lamellar thickness transition of melt-crystallized polybuten-1 tetragonal phase: configurational change in chainfolding directions

Motoi YAMASHITA

期刊论文

Pricing and production strategies in remanufacturing from the perspectives of supply chain: Review and

期刊论文

Modeling of the resilient supply chain system from a perspective of production design changes

期刊论文

Production of rhamnolipids-producing enzymes of

Kata Kiss,Wei Ting Ng,Qingxin Li

期刊论文

Digitalization for supply chain resilience and robustness: The roles of collaboration and formal contracts

期刊论文

Disruptive technologies for advancing supply chain resilience

期刊论文

Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

期刊论文

Advancing food supply chain resilience in the post-pandemic era

期刊论文

Managing supply chain resilience in the era of VUCA

Ying GAO , Zhuo FENG , Shuibo ZHANG

期刊论文

国外ICT供应链安全管理研究及建议

倪光南,陈晓桦,尚燕敏、徐克付

期刊论文

Digital twin-driven smart supply chain

期刊论文

hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chainand the rat light chain

期刊论文

Product decomposition strategy for optimization of supply chain planning

Braulio BRUNAUD, Maria Paz OCHOA, Ignacio E. GROSSMANN

期刊论文

Development of the expressed immunoglobulin μ chain repertoire during maturation of mice B cells

Jingwen LIANG,Yingfeng LUO,Yi SUN,Meng LEI,Bing ZHANG,Songnian HU,Yaofeng ZHAO

期刊论文

How do digital technologies improve supply chain resilience in the COVID-19 pandemic?

期刊论文